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Proceedings of the National Academy of Sciences RSS feed -- current issue
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28 марта, 18:30

Correction for Hou et al., Homeostatic regulation of AMPA receptor expression at single hippocampal synapses [Correction]

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NEUROSCIENCE Correction for “Homeostatic regulation of AMPA receptor expression at single hippocampal synapses,” by Qingming Hou, Dawei Zhang, Larissa Jarzylo, Richard L. Huganir, and Heng-Ye Man, which appeared in issue 2, January 15, 2008, of Proc Natl Acad Sci USA (105:775–780; first published January 3, 2008; 10.1073/pnas.0706447105). The authors note...

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28 марта, 18:30

Correction for Sethna et al., Insights into immune system development and function from mouse T-cell repertoires [Correction]

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BIOPHYSICS AND COMPUTATIONAL BIOLOGY Correction for “Insights into immune system development and function from mouse T-cell repertoires,” by Zachary Sethna, Yuval Elhanati, Chrissy S. Dudgeon, Curtis G. Callan Jr., Arnold J. Levine, Thierry Mora, and Aleksandra M. Walczak, which appeared in issue 9, February 28, 2017, of Proc Natl Acad...

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28 марта, 18:30

Correction for Koop, Crystals creeping out of cracks [Correction]

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COMMENTARY Correction for “Crystals creeping out of cracks,” by Thomas Koop, which appeared in issue 5, January 31, 2017, of Proc Natl Acad Sci USA (114:797–799; first published January 19, 2017; 10.1073/pnas.1620084114). The author notes that panel E in Fig. 1 appeared incorrectly. The corrected figure and its legend appear...

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28 марта, 18:30

Correction for Nielsen et al., Opinion: Gender diversity leads to better science [Correction]

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OPINION Correction for “Opinion: Gender diversity leads to better science,” by Mathias Wullum Nielsen, Sharla Alegria, Love Börjeson, Henry Etzkowitz, Holly J. Falk-Krzesinski, Aparna Joshi, Erin Leahey, Laurel Smith-Doerr, Anita Williams Woolley, and Londa Schiebinger, which appeared in issue 8, February 21, 2017, of Proc Natl Acad Sci USA (114:1740–1742;...

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28 марта, 18:30

Mouse cytomegalovirus M36 and M45 death suppressors cooperate to prevent inflammation resulting from antiviral programmed cell death pathways [Microbiology]

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The complex interplay between caspase-8 and receptor-interacting protein (RIP) kinase RIP 3 (RIPK3) driving extrinsic apoptosis and necroptosis is not fully understood. Murine cytomegalovirus triggers both apoptosis and necroptosis in infected cells; however, encoded inhibitors of caspase-8 activity (M36) and RIP3 signaling (M45) suppress these antiviral responses. Here, we report...

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28 марта, 18:30

Exhaustion-associated regulatory regions in CD8+ tumor-infiltrating T cells [Immunology and Inflammation]

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T-cell exhaustion is a progressive loss of effector function and memory potential due to persistent antigen exposure, which occurs in chronic viral infections and cancer. Here we investigate the relation between gene expression and chromatin accessibility in CD8+ tumor-infiltrating lymphocytes (TILs) that recognize a model tumor antigen and have features...

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28 марта, 18:30

Inhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo [Immunology and Inflammation]

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Constitutive photomorphogenesis 9 (COP9) signalosome 5 (CSN5), an isopeptidase that removes neural precursor cell-expressed, developmentally down-regulated 8 (NEDD8) moieties from cullins (thus termed “deNEDDylase”) and a subunit of the cullin-RING E3 ligase-regulating COP9 signalosome complex, attenuates proinflammatory NF-κB signaling. We previously showed that CSN5 is up-regulated in human atherosclerotic arteries....

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28 марта, 18:30

Receptor Mincle promotes skin allergies and is capable of recognizing cholesterol sulfate [Immunology and Inflammation]

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Sterile (noninfected) inflammation underlies the pathogenesis of many widespread diseases, such as allergies and autoimmune diseases. The evolutionarily conserved innate immune system is considered to play a key role in tissue injury recognition and the subsequent development of sterile inflammation; however, the underlying molecular mechanisms are not yet completely understood....

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28 марта, 18:30

Cathepsin S is the maȷor activator of the psoriasis-associated proinflammatory cytokine IL-36{gamma} [Immunology and Inflammation]

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The proinflammatory cytokine IL-36γ is highly expressed in epithelial cells and is a pivotal mediator of epithelial inflammation. In particular, IL-36γ is strongly associated with the inflammatory skin disease psoriasis. As with other IL-1 cytokines, IL-36γ is expressed as an inactive precursor and must be processed by specific proteases to...

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28 марта, 18:30

Loss of LMOD1 impairs smooth muscle cytocontractility and causes megacystis microcolon intestinal hypoperistalsis syndrome in humans and mice [Genetics]

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Megacystis microcolon intestinal hypoperistalsis syndrome (MMIHS) is a congenital visceral myopathy characterized by severe dilation of the urinary bladder and defective intestinal motility. The genetic basis of MMIHS has been ascribed to spontaneous and autosomal dominant mutations in actin gamma 2 (ACTG2), a smooth muscle contractile gene. However, evidence suggesting...

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28 марта, 18:30

Osmolality/salinity-responsive enhancers (OSREs) control induction of osmoprotective genes in euryhaline fish [Evolution]

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Fish respond to salinity stress by transcriptional induction of many genes, but the mechanism of their osmotic regulation is unknown. We developed a reporter assay using cells derived from the brain of the tilapia Oreochromis mossambicus (OmB cells) to identify osmolality/salinity-responsive enhancers (OSREs) in the genes of O. mossambicus. Genomic...

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28 марта, 18:30

Multitrait successional forest dynamics enable diverse competitive coexistence [Ecology]

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To explain diversity in forests, niche theory must show how multiple plant species coexist while competing for the same resources. Although successional processes are widespread in forests, theoretical work has suggested that differentiation in successional strategy allows only a few species stably to coexist, including only a single shade tolerant....