Источник
Proceedings of the National Academy of Sciences RSS feed -- current issue
Выбор редакции
12 сентября, 23:40

Retraction for Wang et al., Somatic hypermutation maintains antibody thermodynamic stability during affinity maturation [Retractions]

  • 0

BIOCHEMISTRY Retraction for “Somatic hypermutation maintains antibody thermodynamic stability during affinity maturation,” by Feng Wang, Shiladitya Sen, Yong Zhang, Insha Ahmad, Xueyong Zhu, Ian A. Wilson, Vaughn V. Smider, Thomas J. Magliery, and Peter G. Schultz, which was first published February 25, 2013; 10.1073/pnas.1301810110 (Proc Natl Acad Sci USA 110:4261–4266)....

Выбор редакции
12 сентября, 23:40

Correction to Supporting Information for Kliethermes and Crabbe, Genetic independence of mouse measures of some aspects of novelty seeking [SI Correction]

  • 0

GENETICS Correction to Supporting Information for “Genetic independence of mouse measures of some aspects of novelty seeking,” by Christopher L. Kliethermes and John C. Crabbe, which was first published March 21, 2006; 10.1073/pnas.0509724103 (Proc Natl Acad Sci USA 103:5018–5023). The authors note that Fig. S4 appeared incorrectly. The corrected Fig....

Выбор редакции
12 сентября, 23:40

Correction for Holmes et al., Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence [Correction]

  • 0

NEUROSCIENCE Correction for “Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence,” by Sophie E. Holmes, Matthew J. Girgenti, Margaret T. Davis, Robert H. Pietrzak, Nicole DellaGioia, Nabeel Nabulsi, David Matuskey, Steven Southwick, Ronald S. Duman, Richard E. Carson, John H. Krystal, Irina Esterlis, and the...

12 сентября, 23:40

Correction for Koren and Feingold, Aerosol-cloud-precipitation system as a predator-prey problem [Correction]

  • 0

EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES, POPULATION BIOLOGY Correction for “Aerosol–cloud–precipitation system as a predator-prey problem,” by Ilan Koren and Graham Feingold, which was first published July 8, 2011; 10.1073/pnas.1101777108 (Proc Natl Acad Sci USA 108:12227–12232). The authors note that on page 12229, right column, second full paragraph, line 13, “c2...

Выбор редакции
12 сентября, 23:40

Exploring regulation in tissues with eQTL networks [Systems Biology]

  • 0

Characterizing the collective regulatory impact of genetic variants on complex phenotypes is a major challenge in developing a genotype to phenotype map. Using expression quantitative trait locus (eQTL) analyses, we constructed bipartite networks in which edges represent significant associations between genetic variants and gene expression levels and found that the...

Выбор редакции
12 сентября, 23:40

Reactive oxygen species extend insect life span using components of the insulin-signaling pathway [Physiology]

  • 0

Reactive oxygen species (ROS) are well-known accelerants of aging, but, paradoxically, we show that physiological levels of ROS extend life span in pupae of the moth Helicoverpa armigera, resulting in the dormant state of diapause. This developmental switch appears to operate through a variant of the conventional insulin-signaling pathway, as...

Выбор редакции
12 сентября, 23:40

Mechanisms of ovipositor insertion and steering of a parasitic wasp [Physiology]

  • 0

Drilling into solid substrates with slender beam-like structures is a mechanical challenge, but is regularly done by female parasitic wasps. The wasp inserts her ovipositor into solid substrates to deposit eggs in hosts, and even seems capable of steering the ovipositor while drilling. The ovipositor generally consists of three longitudinally...

Выбор редакции
12 сентября, 23:40

5-hydroxymethylcytosine accumulation in postmitotic neurons results in functional demethylation of expressed genes [Neuroscience]

  • 0

5-hydroxymethylcytosine (5hmC) occurs at maximal levels in postmitotic neurons, where its accumulation is cell-specific and correlated with gene expression. Here we demonstrate that the distribution of 5hmC in CG and non-CG dinucleotides is distinct and that it reflects the binding specificity and genome occupancy of methylcytosine binding protein 2 (MeCP2)....

Выбор редакции
12 сентября, 23:40

Differential HspBP1 expression accounts for the greater vulnerability of neurons than astrocytes to misfolded proteins [Neuroscience]

  • 0

Although it is well known that astrocytes are less vulnerable than neurons in neurodegenerative diseases, the mechanism behind this differential vulnerability is unclear. Here we report that neurons and astrocytes show markedly different activities in C terminus of Hsp70-interacting protein (CHIP), a cochaperone of Hsp70. In astrocytes, CHIP is more...

Выбор редакции
12 сентября, 23:40

Compounding effects of sea level rise and fluvial flooding [Sustainability Science]

  • 0

Sea level rise (SLR), a well-documented and urgent aspect of anthropogenic global warming, threatens population and assets located in low-lying coastal regions all around the world. Common flood hazard assessment practices typically account for one driver at a time (e.g., either fluvial flooding only or ocean flooding only), whereas coastal...

Выбор редакции
12 сентября, 23:40

Null effects of boot camps and short-format training for PhD students in life sciences [Social Sciences]

  • 0

Many PhD programs incorporate boot camps and summer bridge programs to accelerate the development of doctoral students’ research skills and acculturation into their respective disciplines. These brief, high-intensity experiences span no more than several weeks and are typically designed to expose graduate students to data analysis techniques, to develop scientific...

Выбор редакции
12 сентября, 23:40

Reputation offsets trust judgments based on social biases among Airbnb users [Social Sciences]

  • 0

To provide social exchange on a global level, sharing-economy companies leverage interpersonal trust between their members on a scale unimaginable even a few years ago. A challenge to this mission is the presence of social biases among a large heterogeneous and independent population of users, a factor that hinders the...