Fast-diffusing p75NTR monomers support apoptosis and growth cone collapse by neurotrophin ligands [Cell Biology]
- 22 октября, 19:01
- PNAS USA
The p75 neurotrophin (NT) receptor (p75NTR) plays a crucial role in balancing survival-versus-death decisions in the nervous system. Yet, despite 2 decades of structural and biochemical studies, a comprehensive, accepted model for p75NTR activation by NT ligands is still missing. Here, we present a single-molecule study of membrane p75NTR in...
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06 декабря, 12:06