ROME (Reuters) - Former Italian Prime Minister Silvio Berlusconi signaled he was back in frontline politics on Wednesday, launching a broadside against the anti-system 5-Star Movement and predicting a surge in support for his party.
Seattle Genetics, Inc. (SGEN) announced that it has submitted a supplemental Biologics License Application (sBLA) to the FDA for Adcetris (brentuximab vedotin) in patients with cutaneous T-cell lymphoma (CTCL).
Key highlights in the biotech sector include positive data on Clovis' (CLVS) PARP inhibitor, Rubraca.
Seattle Genetics, Inc. (SGEN) announced that it will discontinue the phase III study, CASCADE o vadastuximab talirine (SGN-CD33A) in frontline older acute myeloid leukemia (AML) patients.
1. Lyudmila Pavlichenko, Lady Death Lyudmila Pavlichenko. / Archive Photo Lyudmila Pavlichenko is considered the deadliest woman sniper of the Great Patriotic War, with 309 kills to her name, all of them enemy soldiers and officers. Nicknamed “Lady Death” by foreign war reporters, she is the subject of songs and movies. In the Soviet Union, her image twice appeared on postage stamps. Pavlichenko volunteered for frontline service at the age of 25, and joined the combat army after only brief sniper training. Pavlichenko took part in the battles for Odessa and Sevastopol in Ukraine. During these battles, she met a fellow sniper with whom she decided to tie the knot. But soon after applying for permission to marry, Pavlichenko’s fiancé was seriously wounded and died in the hospital. This story forms the basis of the plot of a recent film about Pavlichenko, “Battle for Sevastopol.” Lyudmila Pavlichenko. / TASS Pavlichenko was involved in the defense of Sevastopol practically till the very end. Under the most horrendous conditions, the city stood firm for eight months. In June 1942 Pavlichenko was wounded and evacuated from the city. In less than one year, Pavlichenko eliminated 300 enemy soldiers and officers. It is said that some of Germany’s top snipers were sent to take her out, 36 of whom she neutralized. One of her adversaries, according to media reports, was a German sniper with over 400 kills. Having recovered from injury, Pavlichenko traveled to the United States and Canada as part of a Soviet youth delegation. She was received by U.S. President Franklin Roosevelt, and his wife Eleanor took her on a trip around the country. At meetings in the United States, Pavlichenko urged the Allies to expedite the opening of a second front in Europe. Speaking in Chicago, she stated: “Gentlemen, I am 25 years old. I have already annihilated 309 fascist invaders. Do you not think, gentlemen, that you have been hiding behind my back for too long?” In the United States she was presented with a Colt pistol, and in Canada with a Winchester rifle. The singer Woody Guthrie dedicated the song “Miss Pavlichenko” to her. In 1943 Pavlichenko was awarded the title Hero of the Soviet Union, but she did not return to the front and spent her time training snipers. 2. Aliya Moldagulova Aliya Moldagulova was a sniper of the 54th Rifle Brigade of the 22nd Guards Army. / TASS Born in Kazakhstan, Aliya Moldagulova was in Leningrad when war broke out. In March 1942, the 16-year-old girl was evacuated from the besieged city, along with other children from the orphanage where she lived. By December of that same year, Aliya had enrolled as a cadet at the recently established Central School of Sniper Training Instructors. There she was awarded a personalized rifle for fine marksmanship, and in July of the following year, Aliya was sent to the front. “In August 1943 sniper Aliya Moldagulova joined our brigade. A fragile, very likeable girl from Kazakhstan. Despite only being 18 years old, by October she had 32 fascist kills to her name,” recalls one of Aliya’s fellow women soldiers. The latter also recounts that Aliya was exceptionally brave. Besides being an excellent sniper, she also captured German soldiers and carried the wounded from the battlefield, administering first aid in the process. Aliya was killed during the liberation of the Pskov Region in north-west Russia in January 1944. As told by eyewitnesses, she repeatedly led her fellow fighters on the attack with the cry: “Brothers, soldiers, follow me!” During one such attack, despite being injured by shrapnel, she charged at the enemy. Wounded once more by a German officer, she nevertheless managed to kill her adversary. Aliya later died from wounds sustained during this battle. Her service record includes 78 enemy soldiers and officers killed. The title Hero of the Soviet Union was conferred on her posthumously. The ballet “Aliya” was dedicated to her memory, and the story of her life was told in the 1985 movie “Snipers.” 3. Roza Shanina, The Invisible Horror 3rd Belarus Front. Snipers Roza Shanina, Alexandra Yekimova and Lidia Vdovina (left to right). / TASS Roza Shanina was a kindergarten teacher. She saw frontline action at the age of 19 after two years of badgering the military enlistment office to send her to the front. In June 1943, like Aliya Moldagulova, she enrolled at the Central School of Sniper Training Instructors, graduating with honors. Fellow soldiers recall that on killing her first Nazi in April 1944, she exclaimed: “I killed a person, a person...” However, just a few days later she had ten enemy kills to her name, and in a month's time she was awarded the Order of Glory Third Class. Her trademark technique was the “doublet”—a double shot in one breath. Roza was soon presented with another Order of Glory, this time Second Class. As the first woman to receive this award, it brought her nationwide fame. The frontline newspaper Let’s Destroy the Enemy wrote about her, and the Moscow magazine Ogonyok put her photo on its cover. Foreign journalists dubbed her “the Invisible Horror of East Prussia,” which is where she served from the fall of 1944 onwards. Roza Shanina / Archive image / Colored by Klimbim In her wartime diary, Roza wrote that she did not deserve all this glory. She believed that she had contributed very little to the war effort. Having served for nine months, she was killed in action in January 1945, just three months before victory, while covering the wounded commander of her artillery unit. She is believed to have eliminated 59 Wehrmacht soldiers and officers. Read more: World War II heroes now in color
Jennifer Maravillas for HBR According to the National Academy of Medicine (formerly the Institute of Medicine), the U.S. health care system spends almost a third of its resources — $750 billion annually — on unnecessary services and inefficient care. New predictive analytics tools promise to reduce waste and improve care by forecasting the likelihood of an event — for example, a patient being readmitted to a hospital or developing a life-threatening infection — and allowing providers to tailor treatments and services accordingly. These tools are now being used across the continuum of care, from disease surveillance to chronic disease prevention to identifying patients who are at risk of deterioration. But despite the tools’ power to improve care, most health care institutions are not yet using them. Among the impediments to adoption are the bewildering array of options providers face, from mobile applications to web-based tools to programs that integrate with electronic health records. To better understand what stands in the way of adoption, and what facilitates successful implementation, we interviewed 34 key figures from leading U.S. health systems, policy makers, and predictive analytics vendors. Among our most important findings: Success depends less on the tool itself than on getting buy-in at all levels from the start. Here are three lessons: Engage the Right People from the Outset Regardless of whether a provider is developing predictive analytics in-house, as many large academic medical centers have done, or purchasing tools off the shelf, managers should make sure they are involving the right people throughout the entire process. Homegrown tools require special development expertise, and both these and commercial tools require validation, implementation, evaluation, and ongoing improvement. It’s necessary to have a multidisciplinary team, with clinical, analytics, data science, information technology, and behavior change skill sets available from start to finish. Insight Center The Leading Edge of Health Care Sponsored by Optum How the most innovative providers are creating value. A common reasons these tools are underutilized is that frontline employees don’t fully understand their value. Thus, successful programs start with a problem where predictive analytics can make a clear difference. For example, 50% of newborns with untreated sepsis (blood infection) will die. Therefore, healthy babies are often given antibiotics presumptively — “just in case” — which can lead to complications and increased antibiotic resistance. Clearly, it would be desirable to identify newborns at low risk for infection and spare them the presumptive antibiotics. Kaiser Permanente in Northern California has done just this, using a predictive tool to reduce the use of antibiotics by half without an increase in sepsis-related complications. Demonstrating the clinical impact of a predictive tool can go a long way toward engaging those who will use them. This is particularly important for clinical staff who may otherwise be skeptical of “black box algorithms,” whose inner workings remain hidden from them. Bringing clinical staff on board early allows team members to influence which predictive tools are implemented and how, and to see early results. While this can be time-consuming, the benefits cannot be overstated. This applies to both commercial tools and those developed in-house. Commercial vendors, in fact, may have to work even harder with staff to develop trust in their products. Change Agents and Clinical Champions Are Essential Without a clear implementation plan and staff skilled in supporting behavior change, implementation of a predictive tool can stall. We’ve found that health care organizations that regularly used implementation experts to support change and improve quality across a range of IT and other types of projects had a head start when implementing predictive analytics. These individuals work alongside clinicians to map workflows and identify what might need to change when introducing a new process or tool. They may have a clinical background or one in service redesign or quality improvement. Clinical champions have often proved to be essential in successful predictive analytics implementation — and health IT implementation generally. Any group of change agents should include a subset of well-respected clinicians or other thought leaders in the organization. These individuals should actively reach out to promote the tool, demonstrating its use and educating people about its expected benefits. At one leading public hospital in the Southern U.S., a small number of physicians helped promote the use of predictive models throughout the hospital. Their work gave rise to a center for predictive analytics, and today the institution uses these tools in numerous ways, including to reduce readmissions and to identify patients at risk of sepsis or returning to the intensive care unit. The C-Suite Must Commit Just as important as frontline buy-in is engagement from the top, especially from the CEO. Organizational leaders are often unfamiliar with advanced analytics technology and applications. Educating leadership about a tool’s expected benefits is critical in generating support. One large U.S. academic medical center did this by including tool performance measures in the executive dashboard, making its benefits clear to top management. A tool’s value may be quantified in terms of quality improvement, improved patient or clinician satisfaction, or efficiency gains. One measure that is likely to resonate for management is reduced readmissions among Medicare patients, as hospitals may be financially penalized for readmissions. Models aimed at reducing readmissions among high-risk patients are understandably popular; one model, for example, was shown to reduce the likelihood of readmission for heart failure patients by 26%. Ongoing attention from senior management is vital for the long-term sustainability of predictive tools; the models decalibrate over time and require regular maintenance. Successful organizations take a lifecycle approach to managing and maintaining these tools, which requires budgeting for long-term resource requirements, including investments in improving data quality and infrastructure, recalibration, and in-house data science and technology capability. Where commercial tools are purchased, costs such as software licenses, consulting, or other vendor-related fees also need to be factored into long-term budgets. Implementing predictive analytic tools in health care is a means to an end — where the end should represent an improvement in health or health care outcomes, including lower costs. Fully realizing the benefits from a specific tool requires a structured and thoughtful approach, involving the right people, with the right skills sets, at the right time. As we’ve shown, the key to successful implementation has little to do with the model itself. Success depends on the time, effort, and resources set aside for communication, change management, and making the tool a seamless part of user workflow. Clear, committed leadership and a culture strongly supportive of change and learning are also critical factors. Done well, the result can be an increase in high-value care — that is, targeting appropriate health care to those who need it.
London force says an additional 1,867 officers will carry devices, taking total to 6,400The Metropolitan police will significantly increase the number of officers carrying Taser electronic weapons, to offer them more protection against a rising tide of violence.Under the plans announced on Tuesday, another 1,867 officers will carry the devices, taking the total in the Met to 6,400 of its frontline staff, who police chiefs hope will be better able to defend themselves and the public. Continue reading...
The UN Web TV Channel is available 24 hours a day with selected live programming of United Nations meetings and events as well as with pre-recorded video features and documentaries on various global issues. Watch more Live and on-demand events in six languages directly from UN Web TV at: http://webtv.un.org مشاهدة المزيد من الأحداث الحية وعند الطلب في اللغة العربية مباشر من تلفزيون الأمم المتحدة على شبكة الإنترنت : http://webtv.un.org 欲览更多联合国会议与活动的中文直播与回放内容，请访问联合国网络电视主页：http://webtv.un.org Regardez plus d'événements en direct et à la demande en Français directement de UN Web TV sur: http://webtv.un.org Vea más eventos en directo y a la carta en español directamente desde la Web TV de la ONU en: http://webtv.un.org Смотрите больше прямых трансляций и видеозаписей на русском языке на Веб-телевидении ООН: http://webtv.un.org. ------------------------------------------------------- UNTVchannel/ Live Schedule/ Tuesday, 20 June 10:00 Security Council – The situation in the Middle East, including the Palestinian question 11:40 Press conference by UN Secretary-General, António Guterres 1:15 “24 Hours of Your Life Affected by Organized Crime: How to Protect You and Your Loved Ones” (CR 7) 3:00 Security Council Briefing – The Situation I Burundi Evening Schedule: 8:00pm Press conference by UN Secretary-General, António Guterres Followed by – - Security Council – Middle East/ Palestine - Unicef : Syria Funding Crisis - Unicef : Syria Goodwill Ambassador Muzoon on Books - Unicef: Syria Goodwill Ambassador Muzoon on Education - MSF Kenya: Kibera Souvenirs – Stories from the biggest refugee camp
Following the U.S. Air Force’s downing on June 18 of a Syrian Su-22 fighter jet that is believed to have pounded units of the Syrian Democratic Forces (SDF), Moscow has ended a memorandum of cooperation with the U.S. on preventing air incidents over Syria. The Russian Ministry of Defense described the unilateral actions by American aviation as a gross violation of Syrian sovereignty and the norms of international law. At the same time the ministry described the Pentagon's actions as an act of "military aggression." The situation was aggravated by the fact that Russian aircraft were nearby during the American F/A-18E Super Hornet’s attack against the Syrian Su-22. The Defense Ministry said coalition forces had failed to contact the Russian military through the established communication channel of America’s Al Udeid airbase in Qatar and Russia’s Khmeimim airbase in Syria, and warn the Russian side of a potential incident. Syrian Democratic Forces (SDF) fighters unload boxes of weapons that they said were supplied by the U.S.-led coalition against Islamic State, at the eastern outskirts of Raqqa city. / Reuters In response, Russia's air-defense systems will now track all air targets - drones as well as the coalition's frontline aviation - in areas where Russian aviation is operating west of the Euphrates River. At the same time, the Russian Ministry of Foreign Affairs described the Su-22 incident as an act of assistance to the terrorists that the United States is fighting against. Impact on the war against ISIS The incident will primarily impact the progress of military operations to liberate Raqqa, the Islamic State stronghold in Syria. "No side in the conflict is currently capable of liberating Raqqa on their own. The Kurds, supported by the U.S., don’t have enough heavy equipment to capture the city, so they are limited to laying siege to it. The Syrian army has launched an offensive on Deir ez-Zor but it’s not ready to move to the area where the U.S.-backed opposition is fighting," said Vladimir Yevseyev, a military expert and deputy director of the CIS Institute. A Kurdish fighter from the People's Protection Units (YPG) looks at a smoke after an coalition airstrike in Raqqa, June 16, 2017. / Reuters This battle is one of the bloodiest in the Syrian war and can succeed only through a joint effort, said Yevseyev. The opposition now needs tanks and heavy artillery to smoke out the terrorists ensconced in Raqqa, but it can receive them only with the help of the Syrian government, and in the wake of the Su-22 incident this will prove impossible for a while. "Indeed, the Americans have moved some artillery from their bases in the Middle East to the eastern suburbs of Raqqa. But they are not enough. What is needed now is massive shelling of the areas of concentration of Islamic State militants in Raqqa and to send in highly-skilled special forces units for their subsequent mopping up," said Alexei Ramm, a military analyst at the newspaper, Izvestia. What will Russia do? Experts believe that the rift between Russia and the U.S. is temporary and that in the future both sides will resume cooperation in the region. "For the time being, though, Russian aviation will clear the road to Deir ez-Zor for the Syrian army. In addition, we must fully ensure the defense of Palmyra, so as not to lose it again," Ramm added.
Johnson & Johnson (JNJ) announced that its immunotherapy, Darzalex has been approved for use in combination with Celgene Corporation's (CELG) multiple myeloma drug Pomalyst (pomalidomide) and dexamethasone.
HEBRON, West Bank (Reuters) - The heart of the old city of Hebron is divided, with Israeli military checkpoints, mechanical turnstiles and closed-circuit cameras controlling the movement of Palestinians in and out of an area inhabited by some 800 Jewish settlers.
LONDON (Reuters) - Sidelined for months by his boss Theresa May, Britain's finance minister Philip Hammond has returned to the political frontline, criticizing the prime minister over her recent election campaign and calling for pragmatism in Brexit talks that begin on Monday.
Kyle Mizokami Security, Eurasia For all the talk about the Armata, Moscow might be forced to make due with the tanks it already has. In recent years Russia’s new tank, the T-14 Armata, has attracted an intense amount of interest from the outside world. A “clean-sheet” design, it is the first entirely new tank announced in years and the first entirely new Soviet or Russian tank in decades. Despite the imminent introduction of Armata, the budgetary issues mean the bulk of Russia’s tank forces will consist of older, familiar-looking tanks first introduced in the 1980s and even earlier. Russia currently has 2,700 frontline tanks. These are distributed between approximately thirty-six separate motor rifle (mechanized infantry) and tank brigades, and four motor rifle and tank divisions. In a relatively new development, the Russian Ground Forces have introduced so-called battalion tactical groups, a reinforced all-arms unit capable of independent action consisting of four tank and motor rifle companies, artillery, reconnaissance, engineer and support units. Each Russian maneuver brigade or regiment has approximately two battalion tactical groups. The building block of modern Russian armor continues to be the T-72 family of vehicles, which includes the original T-72, its cousin the T-80 and older-brother T-90 main battle tanks. The oldest of the tanks, the T-72, are three decades old, while the T-80s are slightly newer, dating toward the end of the Cold War. The newest are the T-90s, which are basically a thorough modernization of the T-72. First introduced in 1973, the T-72 main battle tank electrified NATO. Low slung, with a new powerful new gun and beefy armor, it was a considerable step up from the mediocre T-62. The new 2A46M 125-millimeter main gun could fire up to eight rounds a minute, serviced by a new autoloader that took the place of a human loader, allowing the tank turret to remain relatively small despite the larger gun and ammunition. A 780 horsepower diesel engine gave it a top speed of thirty-seven miles an hour on the road. Read full article
Financial Times picture editors showcase the best photographs from around the world
M. Ashraf Haidari Security, Asia Terrorism fed by states and non-state-sponsored radicalism don’t recognize borders. When the Afghan government hosted the first meeting of the Kabul Process for Peace and Security Cooperation on June 6, 2017, terrorists carried out a suicide attack on the ancient Great Mosque of Herat, killing ten fasting worshipers and wounding over twenty others. This followed back-to-back terrorist attacks that killed and injured more than seven hundred innocent civilians in Kabul in less than a week. In flagrant violation of the core tenets of Islam, a religion of peace and tolerance, and the key principles of international humanitarian law, this and many other terrorist attacks on Muslims and non-Muslims around the world have been carried out during the holy month of Ramadan. This demonstrates the ruthlessness of terrorists and their state and non-state sponsors, whom the international community should boldly confront, in line with the UN General Assembly Resolution 60/288, which underpins the UN Global Counter-Terrorism Strategy. The strategy requires that UN member states “consistently, unequivocally, and strongly condemn terrorism in all its forms and manifestations, committed by whomever, wherever, and for whatever purposes, as it constitutes one of the most serious threats to international peace and security.” A daily victim of terrorism with regional and transnational roots, Afghanistan has repeatedly reminded its neighbors—and the broader international community—that terrorism fed by state and non-state sponsored radicalism hardly recognizes borders. Instead, it transcends borders across the globe. Afghanistan doesn’t distinguish between terrorist attacks at home and those that have taken civilian lives in United States, Europe, Iran, Russia, Turkey, China, India and the Middle East. Afghans have long felt the pain of terrorism victims in these nations and continue to make the ultimate sacrifice to defend their country and the rest of the world against the intertwined threats of terrorism and radicalism. Read full article
THE European Commission launched a legal case on Tuesday against Poland, Hungary and the Czech Republic for refusing to take in asylum-seekers, ratcheting up a bitter feud within the 28-nation bloc about
Ofsted says poor leadership led to children being put at risk and that standards had deteriorated since inspection in 2011Gloucestershire county council has been forced to apologise after an Ofsted report into its children’s services division questioned the integrity of the senior leadership team and found that “serious and widespread failures” were putting children at risk.The damning report found that the quality of support given to families had “deteriorated significantly” since a previous “inadequate” rating of some aspects of its performance in 2011. While one area, adoption, was rated “good”, inspectors described a culture in which relationships between managers and frontline social workers had broken down. Continue reading...
http://ru.euronews.com/ Представьте себе мир, где преступники действуют совершенно безнаказанно. Мир, в котором данные Вашей кредитки можно приобрести за 1 доллар, а заработать на таком бизнесе один триллион долларов в год, или 770 000 000 евро. Программа "На линии огня" провела собственное расследование, чтобы понять, как бороться с организованной преступностью в кибер пространстве, а главное - как победить. Эксперты в области кибербезопасности предупреждают, что в 2013 году кибератаки на финансовый сектор станут еще более изощренными и вредоносными и могут привести к миллионам долларов убытков. Наша зависимость от интернета растет, а вместе с этим резко увеличиваются возможности мошенников и преступников. О противостоянии растущей угрозе мы поговорили с Троэлсом Оертиномг, главой Европейского центра по борьбе с кибер-преступлениям и Риком Фергюсоном, директором Trend Micro, компании, разрабатывающей программное обеспечение для защиты информации. Ñ�Ð¾Ñ†Ð¸Ð°Ð»ÑŒÐ½Ñ‹Ðµ Ñ�ÐµÑ‚Ð¸ : YouTube: http://bit.ly/zqVL10 Facebook: http://www.facebook.com/euronewsru Twitter: http://twitter.com/euronewsru